The self timer, mirror lockup and Live View functions of the D3/D3x require unnecessary effort to gain their benefits, and the result is blurred images unless tedious work-arounds are used. The issues could be fixed without hardware changes, but after 3 years or so the issues remain stubbornly present.
This discussion applies to not just the D3x, but the D3, and presumably the D700 and D300. See The Sharpest Image for more on the factors that influence critical sharpness. See also Focus Shift, which bears directly on the issue of which aperture to use for focusing so as maintain sharpness when shooting at another aperture.
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Using mirror lockup (best possible)