First, I am not entirely happy with the file sizes from the Panasonic S1R; they are larger than need be as compressing with zip shows.
Panasonic S1R Multi-Shot High-Res mode and the (optional via settings) single-shot images associated with the multi-shot image: lossless, uncompressed 14-bit.
Panasonic S1R single shot mode: delta encoding, 14-bit base, 10-bit delta, same idea as in other Panasonic cameras, though older cameras are 12-bit base/8bit delta. Delta is scaled separately for each 3 pixels. Formally, this is lossy compression, but this will give precise results on smooth details, in worst case compression-related errors will be less than photon noise (and no Sony-style artifacts).
All crops are really same resolution, 8392x5620 visible area. The crop is performed via EXIF tags (instructing software to crop).